| 2021-05-25 00:05:30Tuesday, May 25, 2021 | Plymouth Gladiators v Poole Pirates | 00:05:30Postponed | P - P | Championship KO Cup, 1st Round, 1st Leg | Plymouth Coliseum |
| 2021-05-29 19:30:57Saturday, May 29, 2021 | Eastbourne Eagles v Poole Pirates | 19:30:577:30 pm | 45 - 44 | Championship | Arlington Stadium |
| 2021-06-04 19:30:24Friday, June 4, 2021 | Glasgow Tigers v Poole Pirates | 19:30:247:30 pm | 52 - 38 | Championship | Peugeot Ashfield Stadium |
| 2021-06-09 19:30:22Wednesday, June 9, 2021 | Poole Pirates v Berwick Bandits | 19:30:227:30 pm | 52 - 38 | Championship | Poole Stadium |
| 2021-06-16 00:05:30Wednesday, June 16, 2021 | Birmingham Brummies v Poole Pirates | 00:05:30Postponed | P - P | Championship | Perry Barr Stadium |
| 2021-06-22 19:00:32Tuesday, June 22, 2021 | Plymouth Gladiators v Poole Pirates | 19:00:327:00 pm | 41 - 49 | Championship KO Cup, 1st Round, 1st Leg | |
| 2021-06-30 19:30:22Wednesday, June 30, 2021 | Poole Pirates v Kent Kings | 19:30:227:30 pm | 58 - 32 | Championship | Poole Stadium |
| 2021-07-13 19:00:30Tuesday, July 13, 2021 | Plymouth Gladiators v Poole Pirates | 19:00:307:00 pm | 45 - 45 | Championship | Plymouth Coliseum |
| 2021-07-21 19:30:19Wednesday, July 21, 2021 | Poole Pirates v Plymouth Gladiators | 19:30:197:30 pm | 61 - 29 | Championship KO Cup, 1st Round, 2nd Leg | Poole Stadium |
| 2021-07-24 19:00:16Saturday, July 24, 2021 | Leicester Lions v Poole Pirates | 19:00:167:00 pm | 43 - 47 | Championship | Paul Chapman & Sons Arena |
| 2021-07-27 18:30:59Tuesday, July 27, 2021 | Kent Kings v Poole Pirates | 18:30:596:30 pm | 38 - 52 | Championship | Central Park Stadium |
| 2021-07-28 19:30:22Wednesday, July 28, 2021 | Poole Pirates v Leicester Lions | 19:30:227:30 pm | 52 - 38 | Championship | Poole Stadium |
| 2021-07-30 08:50:26Friday, July 30, 2021 | Scunthorpe Scorpions v Poole Pirates | 08:50:26Postponed | P - P | Championship | Eddie Wright Raceway |
| 2021-08-04 19:30:22Wednesday, August 4, 2021 | Poole Pirates v Edinburgh Monarchs | 19:30:227:30 pm | 48 - 42 | Championship | Poole Stadium |
| 2021-08-06 08:00:59Friday, August 6, 2021 | Edinburgh Monarchs v Poole Pirates | 08:00:59Postponed | P - P | Championship | Armadale Stadium |
| 2021-08-07 19:00:55Saturday, August 7, 2021 | Berwick Bandits v Poole Pirates | 19:00:557:00 pm | 46 - 44 | Championship | Shielfield Park |
| 2021-08-08 16:00:55Sunday, August 8, 2021 | Newcastle Diamonds v Poole Pirates | 16:00:554:00 pm | 29 - 61 | Championship | Newcastle Stadium |
| 2021-08-11 00:05:22Wednesday, August 11, 2021 | Poole Pirates v Redcar Bears | 00:05:22Postponed | P - P | Championship | Poole Stadium |
| 2021-08-18 19:30:22Wednesday, August 18, 2021 | Poole Pirates v Scunthorpe Scorpions | 19:30:227:30 pm | 57 - 33 | Championship | Poole Stadium |
| 2021-08-20 19:30:02Friday, August 20, 2021 | Redcar Bears v Poole Pirates | 19:30:027:30 pm | 48 - 42 | Championship | Media Prima Arena |
| 2021-08-25 19:30:22Wednesday, August 25, 2021 | Poole Pirates v Newcastle Diamonds | 19:30:227:30 pm | 59 - 31 | Championship | Poole Stadium |
| 2021-08-27 19:30:48Friday, August 27, 2021 | Edinburgh Monarchs v Poole Pirates | 19:30:487:30 pm | 40 - 50 | Championship | Armadale Stadium |
| 2021-08-29 17:00:21Sunday, August 29, 2021 | Poole Pirates v Birmingham Brummies | 17:00:215:00 pm | 57 - 33 | Championship | Poole Stadium |
| 2021-09-01 19:30:03Wednesday, September 1, 2021 | Birmingham Brummies v Poole Pirates | 19:30:037:30 pm | 49 - 41 | Championship | Perry Barr Stadium |
| 2021-09-03 19:30:09Friday, September 3, 2021 | Poole Pirates v Glasgow Tigers | 19:30:097:30 pm | 56 - 34 | Championship | Poole Stadium |
| 2021-09-08 19:30:22Wednesday, September 8, 2021 | Poole Pirates v Plymouth Gladiators | 19:30:227:30 pm | 55 - 35 | Championship | Poole Stadium |
| 2021-09-10 19:30:36Friday, September 10, 2021 | Scunthorpe Scorpions v Poole Pirates | 19:30:367:30 pm | 50 - 34 | Championship | Eddie Wright Raceway |
| 2021-09-18 19:00:12Saturday, September 18, 2021 | Leicester Lions v Poole Pirates | 19:00:127:00 pm | 49 - 41 | Championship KO Cup, Semi-Final, 1st Leg | Paul Chapman & Sons Arena |
| 2021-09-22 19:30:55Wednesday, September 22, 2021 | Poole Pirates v Redcar Bears | 19:30:557:30 pm | 52 - 38 | Championship | Poole Stadium |
| 2021-09-29 19:30:39Wednesday, September 29, 2021 | Poole Pirates v Leicester Lions | 19:30:397:30 pm | 55 - 35 | Championship KO Cup, Semi-Final, 2nd Leg | Poole Stadium |
| 2021-10-13 19:30:59Wednesday, October 13, 2021 | Poole Pirates v Leicester Lions | 19:30:597:30 pm | 48 - 42 | Championship Play-Off, Semi-Final, 1st Leg | Poole Stadium |
| 2021-10-16 19:30:45Saturday, October 16, 2021 | Leicester Lions v Poole Pirates | 19:30:457:30 pm | 40 - 50 | Championship Play-Off, Semi-Final, 2nd Leg | Paul Chapman & Sons Arena |
| 2021-10-23 14:30:47Saturday, October 23, 2021 | Edinburgh Monarchs v Poole Pirates | 14:30:472:30 pm | 42 - 47 | Championship KO Cup Final, 1st Leg | Armadale Stadium |
| 2021-10-26 09:15:35Tuesday, October 26, 2021 | Glasgow Tigers v Poole Pirates | 09:15:35Postponed | P - P | Championship Grand Final, 1st Leg | Peugeot Ashfield Stadium |
| 2021-10-27 19:30:41Wednesday, October 27, 2021 | Poole Pirates v Edinburgh Monarchs | 19:30:417:30 pm | 57 - 33 | Championship KO Cup Final, 2nd Leg | Poole Stadium |
| 2021-10-28 00:05:46Thursday, October 28, 2021 | Glasgow Tigers v Poole Pirates | 00:05:46Postponed | P - P | Championship Grand Final, 1st Leg | Peugeot Ashfield Stadium |
| 2021-10-29 00:05:45Friday, October 29, 2021 | Poole Pirates v Glasgow Tigers | 00:05:45Postponed | P - P | Championship Grand Final, 2nd Leg | Poole Stadium |
| 2021-11-02 19:30:37Tuesday, November 2, 2021 | Glasgow Tigers v Poole Pirates | 19:30:377:30 pm | 50 - 40 | Championship Grand Final, 1st Leg | Peugeot Ashfield Stadium |
| 2021-11-04 19:30:24Thursday, November 4, 2021 | Poole Pirates v Glasgow Tigers | 19:30:247:30 pm | 56 - 34 | Championship Grand Final, 2nd Leg | Poole Stadium |
