| 2021-05-18 07:30:59Tuesday, May 18, 2021 | Kent Kings v Leicester Lions | 07:30:59Postponed | P - P | Championship | Central Park Stadium |
| 2021-05-22 17:55:16Saturday, May 22, 2021 | Leicester Lions v Edinburgh Monarchs | 17:55:16Postponed | P - P | Championship | Paul Chapman & Sons Arena |
| 2021-05-28 19:30:26Friday, May 28, 2021 | Scunthorpe Scorpions v Leicester Lions | 19:30:267:30 pm | 38 - 52 | Championship KO Cup, Quarter-Final, 1st Leg | Eddie Wright Raceway |
| 2021-06-05 18:30:55Saturday, June 5, 2021 | Berwick Bandits v Leicester Lions | 18:30:556:30 pm | 47 - 43 | Championship | Shielfield Park |
| 2021-06-06 16:00:16Sunday, June 6, 2021 | Leicester Lions v Berwick Bandits | 16:00:164:00 pm | 48 - 41 | Championship | Paul Chapman & Sons Arena |
| 2021-06-11 19:30:59Friday, June 11, 2021 | Edinburgh Monarchs v Leicester Lions | 19:30:597:30 pm | 49 - 40 | Championship | Armadale Stadium |
| 2021-06-12 19:00:16Saturday, June 12, 2021 | Leicester Lions v Scunthorpe Scorpions | 19:00:167:00 pm | 50 - 40 | Championship KO Cup, Quarter-Final, 2nd Leg | Paul Chapman & Sons Arena |
| 2021-06-19 19:00:16Saturday, June 19, 2021 | Leicester Lions v Redcar Bears | 19:00:167:00 pm | 51 - 39 | Championship | Paul Chapman & Sons Arena |
| 2021-06-20 16:00:55Sunday, June 20, 2021 | Newcastle Diamonds v Leicester Lions | 16:00:554:00 pm | 49 - 41 | Championship | Newcastle Stadium |
| 2021-06-26 19:00:16Saturday, June 26, 2021 | Leicester Lions v Newcastle Diamonds | 19:00:167:00 pm | 63 - 27 | Championship | Paul Chapman & Sons Arena |
| 2021-07-10 19:00:16Saturday, July 10, 2021 | Leicester Lions v Scunthorpe Scorpions | 19:00:167:00 pm | 57 - 33 | Championship | Paul Chapman & Sons Arena |
| 2021-07-18 15:00:57Sunday, July 18, 2021 | Eastbourne Eagles v Leicester Lions | 15:00:573:00 pm | 41 - 48 | Championship | Arlington Stadium |
| 2021-07-24 19:00:16Saturday, July 24, 2021 | Leicester Lions v Poole Pirates | 19:00:167:00 pm | 43 - 47 | Championship | Paul Chapman & Sons Arena |
| 2021-07-27 19:00:30Tuesday, July 27, 2021 | Plymouth Gladiators v Leicester Lions | 19:00:307:00 pm | 43 - 46 | Championship | Plymouth Coliseum |
| 2021-07-28 19:30:22Wednesday, July 28, 2021 | Poole Pirates v Leicester Lions | 19:30:227:30 pm | 52 - 38 | Championship | Poole Stadium |
| 2021-07-31 19:00:16Saturday, July 31, 2021 | Leicester Lions v Birmingham Brummies | 19:00:167:00 pm | 63 - 27 | Championship | Paul Chapman & Sons Arena |
| 2021-08-07 07:00:56Saturday, August 7, 2021 | Leicester Lions v Edinburgh Monarchs | 07:00:56Postponed | P - P | Championship | Paul Chapman & Sons Arena |
| 2021-08-11 19:30:30Wednesday, August 11, 2021 | Birmingham Brummies v Leicester Lions | 19:30:307:30 pm | 46 - 44 | Championship | Perry Barr Stadium |
| 2021-08-14 19:00:16Saturday, August 14, 2021 | Leicester Lions v Eastbourne Eagles | 19:00:167:00 pm | 56 - 34 | Championship | Paul Chapman & Sons Arena |
| 2021-08-20 12:10:24Friday, August 20, 2021 | Glasgow Tigers v Leicester Lions | 12:10:24Postponed | P - P | Championship | Peugeot Ashfield Stadium |
| 2021-08-21 08:00:16Saturday, August 21, 2021 | Leicester Lions v Glasgow Tigers | 08:00:16Postponed | P - P | Championship | Paul Chapman & Sons Arena |
| 2021-08-28 19:00:16Saturday, August 28, 2021 | Leicester Lions v Plymouth Gladiators | 19:00:167:00 pm | 50 - 40 | Championship | Paul Chapman & Sons Arena |
| 2021-09-03 19:30:26Friday, September 3, 2021 | Scunthorpe Scorpions v Leicester Lions | 19:30:267:30 pm | 39 - 51 | Championship | Eddie Wright Raceway |
| 2021-09-04 19:00:10Saturday, September 4, 2021 | Leicester Lions v Glasgow Tigers | 19:00:107:00 pm | 54 - 36 | Championship | Paul Chapman & Sons Arena |
| 2021-09-11 19:00:26Saturday, September 11, 2021 | Leicester Lions v Edinburgh Monarchs | 19:00:267:00 pm | 47 - 43 | Championship | Paul Chapman & Sons Arena |
| 2021-09-17 19:30:02Friday, September 17, 2021 | Redcar Bears v Leicester Lions | 19:30:027:30 pm | 45 - 45 | Championship | Media Prima Arena |
| 2021-09-18 19:00:12Saturday, September 18, 2021 | Leicester Lions v Poole Pirates | 19:00:127:00 pm | 49 - 41 | Championship KO Cup, Semi-Final, 1st Leg | Paul Chapman & Sons Arena |
| 2021-09-19 18:00:21Sunday, September 19, 2021 | Glasgow Tigers v Leicester Lions | 18:00:21Abandoned | 3 - 3 | Championship | Peugeot Ashfield Stadium |
| 2021-09-21 18:30:02Tuesday, September 21, 2021 | Kent Kings vs Leicester Lions | 18:30:026:30 pm | 37 - 53 | Championship | Central Park Stadium |
| 2021-09-22 09:30:46Wednesday, September 22, 2021 | Glasgow Tigers v Leicester Lions | 09:30:46Postponed | P - P | Championship | Peugeot Ashfield Stadium |
| 2021-09-25 18:00:16Saturday, September 25, 2021 | Leicester Lions v Kent Kings | 18:00:166:00 pm | 52 - 38 | Championship | Paul Chapman & Sons Arena |
| 2021-09-26 15:00:08Sunday, September 26, 2021 | Glasgow Tigers v Leicester Lions | 15:00:083:00 pm | 49 - 41 | Championship | Peugeot Ashfield Stadium |
| 2021-09-29 19:30:39Wednesday, September 29, 2021 | Poole Pirates v Leicester Lions | 19:30:397:30 pm | 55 - 35 | Championship KO Cup, Semi-Final, 2nd Leg | Poole Stadium |
| 2021-10-01 19:30:49Friday, October 1, 2021 | Scunthorpe Scorpions v Leicester Lions | 19:30:497:30 pm | 36 - 54 | Championship Play-Off, Quarter-Final, 1st Leg | Eddie Wright Raceway |
| 2021-10-02 08:20:41Saturday, October 2, 2021 | Leicester Lions v Scunthorpe Scorpions | 08:20:41Postponed | P - P | Championship Play-Off, Quarter-Final, 2nd Leg | Paul Chapman & Sons Arena |
| 2021-10-09 19:30:18Saturday, October 9, 2021 | Leicester Lions v Scunthorpe Scorpions | 19:30:18Postponed | P - P | Championship Play-Off, Quarter-Final, 2nd Leg | Paul Chapman & Sons Arena |
| 2021-10-12 19:30:37Tuesday, October 12, 2021 | Leicester Lions v Scunthorpe Scorpions | 19:30:377:30 pm | 38 - 28 | Championship Play-Off, Quarter-Final, 2nd Leg | Paul Chapman & Sons Arena |
| 2021-10-13 19:30:59Wednesday, October 13, 2021 | Poole Pirates v Leicester Lions | 19:30:597:30 pm | 48 - 42 | Championship Play-Off, Semi-Final, 1st Leg | Poole Stadium |
| 2021-10-16 19:30:45Saturday, October 16, 2021 | Leicester Lions v Poole Pirates | 19:30:457:30 pm | 40 - 50 | Championship Play-Off, Semi-Final, 2nd Leg | Paul Chapman & Sons Arena |
