| 2022-04-13 19:30:00Wednesday, April 13, 2022 | Oxford Cheetahs v Scunthorpe Scorpions | 19:30:007:30 pm | 49 - 40 | Championship | Oxford Stadium |
| 2022-04-15 19:30:00Friday, April 15, 2022 | Poole Pirates v Oxford Cheetahs | 19:30:007:30 pm | 58 - 32 | Championship | Poole Stadium |
| 2022-04-20 19:30:00Wednesday, April 20, 2022 | Oxford Cheetahs v Poole Pirates | 19:30:007:30 pm | 42 - 48 | Championship | Oxford Stadium |
| 2022-04-23 19:00:00Saturday, April 23, 2022 | Berwick Bandits v Oxford Cheetahs | 19:00:007:00 pm | 59 - 31 | Championship | Shielfield Park |
| 2022-04-24 16:00:00Sunday, April 24, 2022 | Newcastle Diamonds v Oxford Cheetahs | 16:00:004:00 pm | 41 - 48 | Championship | Newcastle Stadium |
| 2022-04-27 19:30:00Wednesday, April 27, 2022 | Oxford Cheetahs v Redcar Bears | 19:30:007:30 pm | 47 - 43 | Championship KO Cup, 1st Round, 1st Leg | Oxford Stadium |
| 2022-04-29 19:30:00Friday, April 29, 2022 | Redcar Bears v Oxford Cheetahs | 19:30:007:30 pm | 51 - 39 | Championship KO Cup, 1st Round, 2nd Leg | ECCO Arena |
| 2022-05-07 19:00:00Saturday, May 7, 2022 | Leicester Lions v Oxford Cheetahs | 19:00:007:00 pm | 55 - 35 | Championship | Paul Chapman & Sons Arena |
| 2022-05-10 19:00:00Tuesday, May 10, 2022 | Plymouth Gladiators v Oxford Cheetahs | 19:00:007:00 pm | 55 - 35 | Championship | Plymouth Coliseum |
| 2022-05-11 19:30:00Wednesday, May 11, 2022 | Oxford Cheetahs v Redcar Bears | 19:30:007:30 pm | 47 - 43 | Championship | Oxford Stadium |
| 2022-05-13 19:30:00Friday, May 13, 2022 | Scunthorpe Scorpions v Oxford Cheetahs | 19:30:007:30 pm | 54 - 36 | Championship | Eddie Wright Raceway |
| 2022-05-17 19:30:00Tuesday, May 17, 2022 | Oxford Cheetahs v Birmingham Brummies | 19:30:007:30 pm | 42 - 48 | Championship | Oxford Stadium |
| 2022-05-18 19:30:00Wednesday, May 18, 2022 | Birmingham Brummies v Oxford Cheetahs | 19:30:007:30 pm | 43 - 47 | Championship | Perry Barr Stadium |
| 2022-06-08 19:30:00Wednesday, June 8, 2022 | Oxford Cheetahs v Newcastle Diamonds | 19:30:00Abandoned | 17 - 7 | Championship | Oxford Stadium |
| 2022-06-10 19:30:00Friday, June 10, 2022 | Redcar Bears v Oxford Cheetahs | 19:30:007:30 pm | 47 - 43 | Championship | ECCO Arena |
| 2022-06-17 19:30:00Friday, June 17, 2022 | Glasgow Tigers v Oxford Cheetahs | 19:30:007:30 pm | 53 - 37 | Championship | Peugeot Ashfield Stadium |
| 2022-06-22 19:30:00Wednesday, June 22, 2022 | Oxford Cheetahs v Glasgow Tigers | 19:30:007:30 pm | 46 - 44 | Championship | Oxford Stadium |
| 2022-06-24 19:30:00Friday, June 24, 2022 | Edinburgh Monarchs v Oxford Cheetahs | 19:30:007:30 pm | 48 - 42 | Championship | Armadale Stadium |
| 2022-06-29 19:30:00Wednesday, June 29, 2022 | Oxford Cheetahs v Leicester Lions | 19:30:007:30 pm | 43 - 47 | Championship | Oxford Stadium |
| 2022-07-06 19:30:00Wednesday, July 6, 2022 | Oxford Cheetahs v Plymouth Gladiators | 19:30:007:30 pm | 50 - 40 | Championship | Oxford Stadium |
| 2022-07-13 19:30:00Wednesday, July 13, 2022 | Oxford Cheetahs v Berwick Bandits | 19:30:007:30 pm | 40 - 50 | Championship | Oxford Stadium |
| 2022-07-19 19:30:00Tuesday, July 19, 2022 | Oxford Cheetahs v Birmingham Brummies | 19:30:007:30 pm | 56 - 34 | Championship Jubilee League (Southern) | Oxford Stadium |
| 2022-07-20 19:30:00Wednesday, July 20, 2022 | Birmingham Brummies v Oxford Cheetahs | 19:30:007:30 pm | 46 - 44 | Championship Jubilee League (Southern) | Perry Barr Stadium |
| 2022-07-26 19:00:00Tuesday, July 26, 2022 | Plymouth Gladiators v Oxford Cheetahs | 19:00:007:00 pm | 45 - 45 | Championship Jubilee League (Southern) | Plymouth Coliseum |
| 2022-07-27 19:30:00Wednesday, July 27, 2022 | Oxford Cheetahs v Plymouth Gladiators | 19:30:007:30 pm | 56 - 34 | Championship Jubilee League (Southern) | Oxford Stadium |
| 2022-08-02 19:30:00Tuesday, August 2, 2022 | Oxford Cheetahs v Poole Pirates | 19:30:007:30 pm | 45 - 45 | Championship Jubilee League (Southern) | Oxford Stadium |
| 2022-08-03 19:30:00Wednesday, August 3, 2022 | Poole Pirates v Oxford Cheetahs | 19:30:007:30 pm | 48 - 42 | Championship Jubilee League (Southern) | Poole Stadium |
| 2022-08-17 19:30:00Wednesday, August 17, 2022 | Oxford Cheetahs v Edinburgh Monarchs | 19:30:007:30 pm | 44 - 46 | Championship | Oxford Stadium |
