| 2022-03-26 19:00:00Saturday, March 26, 2022 | Leicester Lions v Birmingham Brummies | 19:00:007:00 pm | 64 - 26 | Championship KO Cup, 1st Round, 1st Leg | Paul Chapman & Sons Arena |
| 2022-04-02 19:00:00Saturday, April 2, 2022 | Leicester Lions v Scunthorpe Scorpions | 19:00:007:00 pm | 62 - 28 | Championship | Paul Chapman & Sons Arena |
| 2022-04-06 19:30:00Wednesday, April 6, 2022 | Birmingham Brummies v Leicester Lions | 19:30:007:30 pm | 30 - 30 | Championship KO Cup, 1st Round, 2nd Leg | Perry Barr Stadium |
| 2022-04-09 19:00:00Saturday, April 9, 2022 | Leicester Lions v Newcastle Diamonds | 19:00:007:00 pm | 65 - 24 | Championship | Paul Chapman & Sons Arena |
| 2022-04-15 17:00:00Friday, April 15, 2022 | Scunthorpe Scorpions v Leicester Lions | 17:00:005:00 pm | 55 - 35 | Championship | Eddie Wright Raceway |
| 2022-04-16 19:00:00Saturday, April 16, 2022 | Leicester Lions v Poole Pirates | 19:00:007:00 pm | 48 - 42 | Championship | Paul Chapman & Sons Arena |
| 2022-04-19 19:00:00Tuesday, April 19, 2022 | Plymouth Gladiators v Leicester Lions | 19:00:007:00 pm | 60 - 30 | Championship | Plymouth Coliseum |
| 2022-04-22 19:30:00Friday, April 22, 2022 | Redcar Bears v Leicester Lions | 19:30:007:30 pm | 48 - 42 | Championship | ECCO Arena |
| 2022-04-23 19:00:00Saturday, April 23, 2022 | Leicester Lions v Glasgow Tigers | 19:00:007:00 pm | 52 - 38 | Championship | Paul Chapman & Sons Arena |
| 2022-04-30 19:00:00Saturday, April 30, 2022 | Leicester Lions v Redcar Bears | 19:00:007:00 pm | 60 - 30 | Championship | Paul Chapman & Sons Arena |
| 2022-05-07 19:00:00Saturday, May 7, 2022 | Leicester Lions v Oxford Cheetahs | 19:00:007:00 pm | 55 - 35 | Championship | Paul Chapman & Sons Arena |
| 2022-05-13 19:30:00Friday, May 13, 2022 | Edinburgh Monarchs v Leicester Lions | 19:30:007:30 pm | 39 - 50 | Championship | Armadale Stadium |
| 2022-05-27 19:30:07Friday, May 27, 2022 | Scunthorpe Scorpions v Leicester Lions | 19:30:07Abandoned | 5 - 7 | Championship KO Cup, Quarter-Final, 1st Leg | Eddie Wright Raceway |
| 2022-05-28 19:00:25Saturday, May 28, 2022 | Leicester Lions v Scunthorpe Scorpions | 19:00:257:00 pm | 58 - 32 | Championship KO Cup, Quarter-Final, 1st Leg | Paul Chapman & Sons Arena |
| 2022-06-01 19:30:00Wednesday, June 1, 2022 | Birmingham Brummies v Leicester Lions | 19:30:007:30 pm | 38 - 52 | Championship | Perry Barr Stadium |
| 2022-06-04 18:30:00Saturday, June 4, 2022 | Berwick Bandits v Leicester Lions | 18:30:006:30 pm | 41 - 49 | Championship | Shielfield Park |
| 2022-06-05 00:05:00Sunday, June 5, 2022 | Leicester Lions v Berwick Bandits | 00:05:00Postponed | P - P | Championship | Paul Chapman & Sons Arena |
| 2022-06-08 19:30:00Wednesday, June 8, 2022 | Poole Pirates v Leicester Lions | 19:30:007:30 pm | 43 - 47 | Championship | Poole Stadium |
| 2022-06-11 18:30:00Saturday, June 11, 2022 | Leicester Lions v Plymouth Gladiators | 18:30:006:30 pm | 48 - 41 | Championship | Paul Chapman & Sons Arena |
| 2022-06-12 16:00:00Sunday, June 12, 2022 | Newcastle Diamonds v Leicester Lions | 16:00:004:00 pm | 28 - 62 | Championship | Newcastle Stadium |
| 2022-06-24 19:30:00Friday, June 24, 2022 | Glasgow Tigers v Leicester Lions | 19:30:007:30 pm | 56 - 34 | Championship | Peugeot Ashfield Stadium |
| 2022-06-25 19:00:00Saturday, June 25, 2022 | Leicester Lions v Birmingham Brummies | 19:00:007:00 pm | 62 - 28 | Championship | Paul Chapman & Sons Arena |
| 2022-06-29 19:30:00Wednesday, June 29, 2022 | Oxford Cheetahs v Leicester Lions | 19:30:007:30 pm | 43 - 47 | Championship | Oxford Stadium |
| 2022-07-15 19:30:00Friday, July 15, 2022 | Redcar Bears v Leicester Lions | 19:30:007:30 pm | 51 - 39 | Championship Jubilee League (Northern) | ECCO Arena |
| 2022-07-16 18:30:00Saturday, July 16, 2022 | Leicester Lions v Edinburgh Monarchs | 18:30:006:30 pm | 47 - 42 | Championship | Paul Chapman & Sons Arena |
| 2022-07-22 19:30:00Friday, July 22, 2022 | Scunthorpe Scorpions v Leicester Lions | 19:30:007:30 pm | 46 - 44 | Championship Jubilee League (Northern) | Eddie Wright Raceway |
| 2022-07-24 18:00:51Sunday, July 24, 2022 | Leicester Lions v Berwick Bandits | 18:00:516:00 pm | 55 - 35 | Championship | Paul Chapman & Sons Arena |
| 2022-07-30 19:00:00Saturday, July 30, 2022 | Leicester Lions v Redcar Bears | 19:00:007:00 pm | 51 - 39 | Championship Jubilee League (Northern) | Paul Chapman & Sons Arena |
| 2022-08-06 19:00:00Saturday, August 6, 2022 | Leicester Lions v Scunthorpe Scorpions | 19:00:007:00 pm | 56 - 34 | Championship Jubilee League (Northern) | Paul Chapman & Sons Arena |
| 2022-09-02 19:30:28Friday, September 2, 2022 | Scunthorpe Scorpions v Leicester Lions | 19:30:287:30 pm | 45 - 45 | Championship KO Cup, Quarter-Final, 2nd Leg | Eddie Wright Raceway |
| 2022-09-10 00:05:13Saturday, September 10, 2022 | Leicester Lions v Poole Pirates | 00:05:13Postponed | P - P | Championship KO Cup, Semi-Final, 1st Leg | Paul Chapman & Sons Arena |
| 2022-09-17 19:00:25Saturday, September 17, 2022 | Leicester Lions v Poole Pirates | 19:00:257:00 pm | 46 - 44 | Championship KO Cup, Semi-Final, 1st Leg | Paul Chapman & Sons Arena |
| 2022-09-21 19:30:54Wednesday, September 21, 2022 | Poole Pirates v Leicester Lions | 19:30:547:30 pm | 60 - 30 | Championship KO Cup, Semi-Final, 2nd Leg | Poole Stadium |
| 2022-09-23 19:30:13Friday, September 23, 2022 | Edinburgh Monarchs v Leicester Lions | 19:30:137:30 pm | 36 - 53 | Championship Play-Off, Semi-Final, 1st Leg | Armadale Stadium |
| 2022-09-24 19:00:19Saturday, September 24, 2022 | Leicester Lions v Edinburgh Monarchs | 19:00:197:00 pm | 53 - 37 | Championship Play-Off, Semi-Final, 2nd Leg | Paul Chapman & Sons Arena |
| 2022-10-21 00:05:50Friday, October 21, 2022 | Poole Pirates v Leicester Lions | 00:05:50Postponed | P - P | Championship Grand Final, 1st Leg | Poole Stadium |
| 2022-10-22 11:00:27Saturday, October 22, 2022 | Leicester Lions v Poole Pirates | 11:00:27Postponed | P - P | Championship Grand Final, 1st Leg | Paul Chapman & Sons Arena |
| 2022-10-25 13:30:22Tuesday, October 25, 2022 | Premiership Pairs - Round 5 @ Leicester | 13:30:22Postponed | P - P | Premiership Pairs, Round 5 | Paul Chapman & Sons Arena |
| 2022-10-26 19:30:21Wednesday, October 26, 2022 | Poole Pirates v Leicester Lions | 19:30:217:30 pm | 49 - 41 | Championship Grand Final, 1st Leg | Poole Stadium |
| 2022-10-29 09:15:29Saturday, October 29, 2022 | Leicester Lions v Poole Pirates | 09:15:29Postponed | P - P | Championship Grand Final, 2nd Leg | Paul Chapman & Sons Arena |
| 2022-10-30 09:43:31Sunday, October 30, 2022 | Leicester Lions v Poole Pirates | 09:43:31Postponed | P - P | Championship Grand Final, 2nd Leg | Paul Chapman & Sons Arena |
| 2022-10-31 00:05:20Monday, October 31, 2022 | Premiership Pairs - Round 6 @ Leicester | 00:05:20Postponed | P - P | Premiership Pairs, Round 6 | Paul Chapman & Sons Arena |
| 2022-11-04 19:00:39Friday, November 4, 2022 | Leicester Lions v Poole Pirates | 19:00:397:00 pm | 38 - 52 | Championship Grand Final, 2nd Leg | Adrian Flux Arena |
