| 2022-04-05 19:00:00Tuesday, April 5, 2022 | Plymouth Gladiators v Poole Pirates | 19:00:007:00 pm | 42 - 48 | Championship KO Cup, Quarter-Final, 1st Leg | Plymouth Coliseum |
| 2022-04-06 19:30:00Wednesday, April 6, 2022 | Poole Pirates v Plymouth Gladiators | 19:30:007:30 pm | 58 - 32 | Championship KO Cup, Quarter-Final , 2nd Leg | Poole Stadium |
| 2022-04-08 19:30:00Friday, April 8, 2022 | Redcar Bears v Plymouth Gladiators | 19:30:007:30 pm | 48 - 42 | Championship | ECCO Arena |
| 2022-04-19 19:00:00Tuesday, April 19, 2022 | Plymouth Gladiators v Leicester Lions | 19:00:007:00 pm | 60 - 30 | Championship | Plymouth Coliseum |
| 2022-04-26 19:00:00Tuesday, April 26, 2022 | Plymouth Gladiators v Scunthorpe Scorpions | 19:00:007:00 pm | 48 - 42 | Championship | Plymouth Coliseum |
| 2022-04-29 19:30:00Friday, April 29, 2022 | Scunthorpe Scorpions v Plymouth Gladiators | 19:30:007:30 pm | 42 - 48 | Championship | Eddie Wright Raceway |
| 2022-05-03 19:00:00Tuesday, May 3, 2022 | Plymouth Gladiators v Poole Pirates | 19:00:007:00 pm | 53 - 37 | Championship | Plymouth Coliseum |
| 2022-05-06 19:30:00Friday, May 6, 2022 | Glasgow Tigers v Plymouth Gladiators | 19:30:007:30 pm | 49 - 41 | Championship | Peugeot Ashfield Stadium |
| 2022-05-10 19:00:00Tuesday, May 10, 2022 | Plymouth Gladiators v Oxford Cheetahs | 19:00:007:00 pm | 55 - 35 | Championship | Plymouth Coliseum |
| 2022-05-17 19:00:00Tuesday, May 17, 2022 | Plymouth Gladiators v Berwick Bandits | 19:00:007:00 pm | 49 - 41 | Championship | Plymouth Coliseum |
| 2022-05-31 19:00:00Tuesday, May 31, 2022 | Plymouth Gladiators v Edinburgh Monarchs | 19:00:007:00 pm | 48 - 42 | Championship | Plymouth Coliseum |
| 2022-06-07 08:09:00Tuesday, June 7, 2022 | Plymouth Gladiators v Birmingham Brummies | 08:09:00Postponed | P - P | Championship | Plymouth Coliseum |
| 2022-06-11 18:30:00Saturday, June 11, 2022 | Leicester Lions v Plymouth Gladiators | 18:30:006:30 pm | 48 - 41 | Championship | Paul Chapman & Sons Arena |
| 2022-06-15 19:30:00Wednesday, June 15, 2022 | Birmingham Brummies v Plymouth Gladiators | 19:30:007:30 pm | 46 - 44 | Championship | Perry Barr Stadium |
| 2022-06-21 09:16:00Tuesday, June 21, 2022 | Plymouth Gladiators v Newcastle Diamonds | 09:16:00Postponed | P - P | Championship | Plymouth Coliseum |
| 2022-06-22 19:30:00Wednesday, June 22, 2022 | Poole Pirates v Plymouth Gladiators | 19:30:007:30 pm | 45 - 45 | Championship | Poole Stadium |
| 2022-06-28 00:05:00Tuesday, June 28, 2022 | Plymouth Gladiators v Glasgow Tigers | 00:05:00Postponed | P - P | Championship | Plymouth Coliseum |
| 2022-07-06 19:30:00Wednesday, July 6, 2022 | Oxford Cheetahs v Plymouth Gladiators | 19:30:007:30 pm | - | Championship | Oxford Stadium |
| 2022-07-12 19:00:00Tuesday, July 12, 2022 | Plymouth Gladiators v Birmingham Brummies | 19:00:007:00 pm | - | Summer Trophy (Southern) | Plymouth Coliseum |
| 2022-07-13 19:30:00Wednesday, July 13, 2022 | Birmingham Brummies v Plymouth Gladiators | 19:30:007:30 pm | - | Summer Trophy (Southern) | Perry Barr Stadium |
| 2022-07-19 19:00:00Tuesday, July 19, 2022 | Plymouth Gladiators v Poole Pirates | 19:00:007:00 pm | - | Summer Trophy (Southern) | Plymouth Coliseum |
| 2022-07-26 19:00:00Tuesday, July 26, 2022 | Plymouth Gladiators v Oxford Cheetahs | 19:00:007:00 pm | - | Summer Trophy (Southern) | Plymouth Coliseum |
| 2022-07-27 19:30:00Wednesday, July 27, 2022 | Oxford Cheetahs v Plymouth Gladiators | 19:30:007:30 pm | - | Summer Trophy (Southern) | Oxford Stadium |
| 2022-08-02 19:00:42Tuesday, August 2, 2022 | Plymouth Gladiators v Birmingham Brummies | 19:00:427:00 pm | - | Championship | Plymouth Coliseum |
| 2022-08-05 19:30:00Friday, August 5, 2022 | Edinburgh Monarchs v Plymouth Gladiators | 19:30:007:30 pm | - | Championship | Armadale Stadium |
| 2022-08-06 18:30:00Saturday, August 6, 2022 | Berwick Bandits v Plymouth Gladiators | 18:30:006:30 pm | - | Championship | Shielfield Park |
| 2022-08-10 19:30:00Wednesday, August 10, 2022 | Poole Pirates v Plymouth Gladiators | 19:30:007:30 pm | - | Summer Trophy (Southern) | Poole Stadium |
| 2022-08-16 19:00:00Tuesday, August 16, 2022 | Plymouth Gladiators v Redcar Bears | 19:00:007:00 pm | - | Championship | Plymouth Coliseum |
